Analogs of phenothiazines. 5. Synthesis and neuropharmacological activity of some piperidylidene derivatives of thioxanthenes, xanthenes, dibenzoxepins, and …

C Kaiser, PJ Fowler, DH Tedeschi…

Index: Kaiser,C. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 57 - 62

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Citation Number: 23

Abstract

A series of piperidylidene derivatives of thioxanthenes, xanthenes, dibenzoxepins, and acridans was prepared and examined for neuropharmacological activity. Several of these compounds having an appropriate substituent, eg, CF3, C1, SMe, in the 2 position of the tricyclic nucleus were potent neuroleptic agents. For example, in a ptosis production test in rats l-methyl-4-(2-trifluoromethylthioxanthen-9-ylidene) piperidine (11) and its 10- ...