Chemistry–A European Journal

Copper??Catalyzed Asymmetric Conjugate Addition with Chiral SimplePhos Ligands

L Palais, A Alexakis

Index: Palais, Laetitia; Alexakis, Alexandre Chemistry - A European Journal, 2009 , vol. 15, # 40 p. 10473 - 10485

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Citation Number: 50

Abstract

Abstract SimplePhos ligands represent a novel class of monodentate chiral ligands based on a chiral amine moiety and flexible diaryl groups on the phosphorous atom. They can be easily prepared by two different pathways and they can be highly functionalised. Herein we report the copper-catalysed asymmetric conjugate addition of diethyl zinc and trialkylaluminium reagents with SimplePhos ligands, which gives high enantioselectivity ...