Tetrahedron: asymmetry

Removal of the acyl donor residue allows the use of simple alkyl esters as acyl donors for the dynamic kinetic resolution of secondary alcohols

GKM Verzijl, JG de Vries, QB Broxterman

Index: Verzijl, Gerard K.M.; De Vries, Johannes G.; Broxterman, Quirinus B. Tetrahedron Asymmetry, 2005 , vol. 16, # 9 p. 1603 - 1610

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Citation Number: 50

Abstract

The dynamic kinetic resolution of secondary alcohols using a lipase and a ruthenium catalyst as developed by Bäckvall required some improvements to make it suitable for its use in an industrial process. The use of p-chlorophenyl acetate as acyl donor is not desirable in view of the toxicity of the side product. We herein report that simple alkyl esters can be used as acyl donors if the alcohol or ketone residue formed during the enzymatic ...