Electronic control of chiral quaternary center creation in the intramolecular asymmetric Heck reaction

…, JC Lorenz, KB McKellop, EM O'Brien…

Index: Bucassa, Carl A.; Grossbach, Danja; Campbell, Scot J.; Dong, Yong; Eriksson, Magnus C.; Harris, Robert E.; Jones, Paul-James; Kim, Ji-Young; Lorenz, Jon C.; McKellop, Keith B.; O'Brien, Erin M.; et al. Journal of Organic Chemistry, 2004 , vol. 69, # 16 p. 5187 - 5195

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Citation Number: 38

Abstract

The Boehringer-Ingelheim phosphinoimidazoline (BIPI) ligands were applied to the formation of chiral quaternary centers in the asymmetric Heck reaction. Several different substrates were examined in detail, using more than 70 members of this new ligand class. Hammett relationships were determined through systematic variation of the ligand electronics. All substrates showed essentially the same Hammett behavior, where ...