Synthesis and Investigations on the Oxidative Degradation of C3/C5??Alkyl??1, 2, 4??triarylpyrroles as Ligands for the Estrogen Receptor

A Schäfer, A Wellner, R Gust

Index: Schaefer, Anja; Wellner, Anja; Gust, Ronald ChemMedChem, 2011 , vol. 6, # 5 p. 794 - 803

Full Text: HTML

Citation Number: 9

Abstract

Abstract In this study, we synthesized 1, 2, 4-triarylpyrroles as ligands for the estrogen receptor (ER). Two pyrrole series were prepared with either C3-alkyl or C3/C5-dialkyl residues. Compounds from both series were susceptible to oxidative degradation— dialkylated compounds (t 1/2= 33–66 h) to a higher extent than their monoalkylated congeners (t 1/2= 140–211 h). Nevertheless, stability was sufficient for determination of in ...