Cobalt (I)??Catalyzed Asymmetric [2+ 2+ 2] Cycloaddition of Alkynes and Nitriles: Synthesis of Enantiomerically Enriched Atropoisomers of 2??Arylpyridines

…, C Fischer, HJ Drexler, A Spannenberg…

Index: Gutnov, Andrey; Heller, Barbara; Fischer, Christine; Drexler, Hans-Joachim; Spannenberg, Anke; Sundermann, Bernd; Sundermann, Corinna Angewandte Chemie - International Edition, 2004 , vol. 43, # 29 p. 3795 - 3797

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Citation Number: 137

Abstract

The [2+ 2+ 2] cycloaddition of alkynes and nitriles is a useful tool in organic synthesis, allowing easy access to a broad variety of benzene and pyridine derivatives in one step. Although achiral reactions of this type are well documented,[1] there are only two examples of catalytic asymmetric [2+ 2+ 2] homocyclizations yielding benzene derivatives with simultaneous introduction of an element of chirality.[2, 3]