Ruthenium??Catalyzed Chemoselective N??Allyl Cleavage: Novel Grubbs Carbene Mediated Deprotection of Allylic Amines

B Alcaide, P Almendros…

Index: Alcaide, Benito; Almendros, Pedro; Alonso, Jose M. Chemistry - A European Journal, 2003 , vol. 9, # 23 p. 5793 - 5799

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Citation Number: 80

Abstract

Abstract A novel application of the Grubbs carbene complex has been discovered. The first examples of the catalytic deprotection of allylic amines with reagents other than palladium catalysts have been achieved through Grubbs carbene mediated reaction. Significantly, the catalytic system directs the reaction toward the selective deprotection of allylic amines (secondary as well as tertiary) in the presence of allylic ethers. A variety of substrates, ...