Journal of medicinal chemistry

ι-(2-Mercaptoethylamino)-1-alkanesulfonic Acid Inner Salts and Related Compounds as Potential Antiradiation Agents1

TP Johnston, CR Stringfellow Jr

Index: Johnston,T.P.; Stringfellow,C.R. Journal of Medicinal Chemistry, 1966 , vol. 9, p. 921 - 924

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Citation Number: 7

Abstract

Reactions of sult, ones la aiid lb with cystamine, sodium S-2-aminoethylthiosulfate, and thiones, such as thiosemicarbazide and pyridine-2 (1H)-thione, provided a number of sulfonic acid inner salt derivatives for testing as antiradiation agents. Catalytic hydrogenolysis of the cystamine derivatives afforded~(2-mercaptoethy1amino)-1- alkanevulfonic acids 3a and 3b. Sulfoalkylation products of 2-thiazolidinethione were ...