Tetrahedron letters

Manipulating reduction potentials in an artificial safranin cofactor

G Raju, J Capo, BR Lichtenstein, JF Cerda, RL Koder

Index: Raju, Gheevarghese; Capo, Joseph; Lichtenstein, Bruce R.; Cerda, Jose F.; Koder, Ronald L. Tetrahedron Letters, 2012 , vol. 53, # 10 p. 1201 - 1203

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Citation Number: 4

Abstract

Safranines hold great promise as artificial flavin-like electron transfer cofactors with tunable properties. We report the design and chemical synthesis of the p-methoxy derivative of safranine O using a new synthetic route based on the Ulmann condensation. Spectroelectrochemical comparison of the purified parent safranine and this derivative demonstrates that the modification increases its two-electron reduction potential by ...