A Novel Method for the Preparation of p-Methoxybenzyloxycarbonyl Amino Acids

S Sofuku, M Mizumura, A Hagitani

Index: Sofuku,S. et al. Bulletin of the Chemical Society of Japan, 1969 , vol. 42, p. 278

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Citation Number: 6

Abstract

The p-methoxybenzyloxycarbonyl(pMZ-) group1, 2) has been widely used as a blocking substituent of the amino moiety of amino acids in peptide synthesis. In the present investigation, it was found that pMZ-amino acids were prepared directly from a number of amino acids and pmethoxybenzyl chloroformate3, 4)(I) under the conditions of the Schotten- Baumann reaction. The reagent(I) was prepared as follows: a solution of anisyl alcohol( ...