Synthesis and antiarrhythmic activity of cis-2, 6-dimethyl-. alpha.,. alpha.-diaryl-1-piperidinebutanols

…, RW Fleming, S Hastings, JM Hinkley…

Index: Hoefle, M. L.; Blouin, L. T.; Fleming, R. W.; Hastings, S.; Hinkley, J. M.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 12 - 19

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Citation Number: 9

Abstract

A series of a, a-diaryl-1-piperidinebutanols was evaluated for antiarrhythmic activity in the coronary ligated dog model. Structure-activity relationship studies indicated that the 2, Ci- dimethylpiperidine group yielded compounds with the best antiarrythmic profiles in this series. The length of the methylene chain separating the diarylcarbinol and the amino group was not crucial. Substitution of a hydrogen or a number of functional groups for the ...