Nucleosides & nucleotides

4-Substituted-5 (3)-carbamoyl-3 (5)-(2-deoxy-β-d-ribofuranosyl) pyrazoles. Application of Palladium Catalyzed Glycal Coupling Methodology to the Synthesis of …

MD Erion, RM Rydzewski†

Index: Erion, Mark D.; Rydzewski, Robert M. Nucleosides and Nucleotides, 1997 , vol. 16, # 3 p. 315 - 337

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Citation Number: 12

Abstract

Abstract Analogs of the C-nucleoside pyrazofurin were prepared in 7–9 steps using a key Pd (0)-catalyzed coupling reaction between protected iodopyrazoles 6a and 6b and glycal 8 to form the glycosyl bond. Conditions for this reaction were improved from those previously described for related reactions in order to maximize product yields and eliminate the need for triphenylarsine.† present address: Arris Pharmaceutical, 385 Oyster Point Blvd., South ...