Asian Journal of Chemistry

A Novel Synthesis of (4aS, 7aS)-Octahydro-1H-pyrrolo [3, 4-b] pyridine: An Intermediate of Moxifloxacin Hydrochloride

GP Reddy, R Bandichhor

Index: Reddy, G. Prashanth; Bandichhor, Rakeshwar Asian Journal of Chemistry, 2013 , vol. 25, # 15 p. 8701 - 8707

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Abstract

Abstract A novel synthesis of (4aS, 7aS)-octahydro-1H-pyrrolo [3, 4-b] pyridine (1) is demonstrated alongwith recovery and reuse of chiral auxiliary naproxen. Further to this alternative stereoselective reduction procedures on 6-benzyl-5H-pyrrolo [3, 4-b] pyridine-5, 7 (6H)-dione 3 enabling the desired chirality in the nonane 1 is demonstrated.

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