N-Triazinylammonium tetrafluoroborates. A new generation of efficient coupling reagents useful for peptide synthesis

ZJ Kaminski, B Kolesinska, J Kolesinska…

Index: Kaminski, Zbigniew J.; Kolesinska, Beata; Kolesinska, Justyna; Sabatino, Giuseppina; Chelli, Mario; Rovero, Paolo; Blaszczyk, Michal; Glowka, Marek L.; Papini, Anna Maria Journal of the American Chemical Society, 2005 , vol. 127, # 48 p. 16912 - 16920

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Citation Number: 111

Abstract

A new generation of triazine-based coupling reagents (TBCRs), designed according to the concept of “superactive esters”, was obtained by treatment of 4-(4, 6-dimethoxy-1, 3, 5-triazin- 2-yl)-4-methylmorpholinium (DMTMM) chloride with lithium or silver tetrafluoroborate. The structure of 4-(4, 6-dimethoxy-1, 3, 5-triazin-2-yl)-4-methylmorpholinium tetrafluoroborate was confirmed by X-ray diffraction. Activation of carboxylic acids by using this reagent ...