Substituted dihydronaphthalenes as efflux pump inhibitors of Staphylococcus aureus

…, MV Reddy, A Kumar, IA Khan, PL Sangwan…

Index: Thota, Niranjan; Reddy, Mallepally V.; Kumar, Ashwani; Khan, Inshad A.; Sangwan, Payare L.; Kalia, Nitin P.; Koul, Jawahir L.; Koul, Surrinder European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 3607 - 3616

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Citation Number: 14

Abstract

A new series of 3-(substituted-3, 4-dihydronaphthyl)-2-propenoic acid amides has been prepared through convergent synthetic strategies and tested in combination with ciprofloxacin against NorA overexpressing Staphylococcus aureus 1199B as test strain for potentiating of the drug activity. Out of 24 compounds evaluated, 12 compounds potentiated the activity of ciprofloxacin and resulted in 2–16 fold reduction in the MIC (4–0.5 μg/mL) of ...