Induction of promotive rather than suppressive immune responses from a novel NKT cell repertoire Vα19 NKT cell with α-mannosyl ceramide analogues consisting of …

…, YY Huang, J Yasuoka, K Morita, A Nishiyama…

Index: Shimamura, Michio; Okamoto, Naoki; Huang, Yi-Ying; Yasuoka, Jouji; Morita, Kenji; Nishiyama, Akira; Amano, Yuusuke; Mishina, Tadashi European Journal of Medicinal Chemistry, 2006 , vol. 41, # 5 p. 569 - 576

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Citation Number: 15

Abstract

A 2-substituted 2-aminopropane-1, 3-diol or 2-aminoethanol is the minimum structure required for the immunosuppressive activity of ISP-I, an antibiotic isolated from the culture broth of Isaria sinclairil. A series of α-mannosyl ceramide (α-ManCer) analogues was derived from 2-substituted 2-aminopropane-1, 3-diols or 2-aminoethanols in place of sphingosine. The newly synthesized glycosides were evaluated for their effects on ...