Bioorganic & medicinal chemistry

Synthesis and preliminary evaluation of some pyrazine containing thiazolines and thiazolidinones as antimicrobial agents

CG Bonde, NJ Gaikwad

Index: Bonde, Chandrakant G.; Gaikwad, Naresh J. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2151 - 2161

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Citation Number: 235

Abstract

A series of N′-[3, 4-disubstituted-1, 3-thiazol-2 (3H)-ylidene]-2-(pyrazin-2-yloxy) acetohydrazide 11–66 and N′-[(2Z)-3-(4-bromophenyl)-4-oxo-1, 3-thiazolidin-2-ylidene]-2- (pyrazin-2-yloxy) acetohydrazide 68–74 were synthesized using appropriate synthetic route. The entire test compounds 11–66 and 68–74 were assayed in vitro for antibacterial activity against two different strains of Gram-negative (E. coli and S. typhi), Gram-positive (S. ...