Synthesis of potential drug metabolites by a modified Udenfriend reaction
R Slavik, JU Peters, R Giger, M Bürkler, E Bald
Index: Slavik, Roger; Peters, Jens-Uwe; Giger, Rudolf; Buerkler, Markus; Bald, Eric Tetrahedron Letters, 2011 , vol. 52, # 7 p. 749 - 752
Full Text: HTML
Citation Number: 5
Abstract
Several drugs (clozapine, chlorpromazine, imipramine, buspirone, diltiazem, and propranolol) were subjected to modified Udenfriend conditions (Fe2+/Mn2+/EDTA/ascorbic acid/O2). From each reaction, one to four oxidation products were obtained in 1–8% overall yield. Many of these products (9 out of 14) have been reported to be metabolites of the parent drugs in vivo. The products resulted mainly from aromatic hydroxylation, and are ...
Related Articles:
Synthesis of possible metabolites of chlorpromazine. II. 3??, 8??and 9??hydroxychlorpromazine
[Nodiff,E.A. et al. Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177]
Synthesis of possible metabolites of chlorpromazine. II. 3??, 8??and 9??hydroxychlorpromazine
[Nodiff,E.A. et al. Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177]
Synthesis of possible metabolites of chlorpromazine. II. 3??, 8??and 9??hydroxychlorpromazine
[Nodiff,E.A. et al. Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177]
Synthesis of possible metabolites of chlorpromazine. II. 3??, 8??and 9??hydroxychlorpromazine
[Nodiff,E.A. et al. Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177]