Medicinal chemical studies on antiplasmin drugs. 4. Chemical modification of trans-4-aminomethylcyclohexanecarboxylic acid and its effect on antiplasmin activity

…, S Funabashi, M Iwamoto, S Isoda…

Index: Okano; Inaoka; Funabashi; Iwamoto; Isoda Journal of medicinal chemistry, 1972 , vol. 15, # 3 p. 247 - 255

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Citation Number: 23

Abstract

A series of N-substituted derivatives, amides, and esters of trans-4- aminomethylcyclohexanecarboxylic acid (trans-AMCHA) were synthesized and evaluated for their antiplasmin activity. Among those, Ph ester derivatives were found to be superior to trans-AMCHA. 1n particular, a high order of the activity was achieved with para-substituted Ph esters. This paper reports the synthetic method, the antiplasmin activity, and the ...