Synthesis and evaluation of 2-nonylaminopyridine derivatives as PPAR ligands

…, H Fujieda, T Suzuki, N Yoshida, H Nakagawa…

Index: Usui, Shinya; Fujieda, Hiroki; Suzuki, Takayoshi; Yoshida, Naoaki; Nakagawa, Hidehiko; Ogura, Michitaka; Makishima, Makoto; Miyata, Naoki Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 7 p. 1053 - 1059

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Citation Number: 8

Abstract

To find novel PPAR ligands, we prepared several 3-{3 or 4-[2-(nonylpyridin-2-ylamino) ethoxy] phenyl} propanoic acid derivatives which were designed based on the structure of our previous PPARγ ligand 1. In PPAR binding affinity assays, compound 4, which had an ethoxy group at the C-2 position of the propanoic acid of 1, showed selective binding affinity for PPARγ. Compound 3, with an ethyl group at the C-2 position, was found to be a ...