Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl] acrylic acid amides and their antimalarial activity

…, J Wiesner, K Silber, P Haebel, R Ortmann…

Index: Wiesner; Mitsch; Altenkaemper; Ortmann; Jomaa; Schlitzer, Martin Pharmazie, 2003 , vol. 58, # 12 p. 854 - 856

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Citation Number: 25

Abstract

Water solubility was previously found to be essential for in vivo-antimalarial activity of a novel type of benzophenone-based farnesyltransferase inhibitors. Introduction of a α-amino group into the phenylacetic acid substructure provided more soluble compounds with high

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