Tetrahedron

A novel synthesis of AZT

C Gauthier, Y Ramondenc, G Plé

Index: Gauthier, Christine; Ramondenc, Yvan; Ple, Gerard Tetrahedron, 2001 , vol. 57, # 35 p. 7513 - 7517

Full Text: HTML

Citation Number: 11

Abstract

A novel synthesis of AZT has been achieved from two commercial available products acetaldehyde and d-mannitol. The originality of the synthesis consists of using the powerful monovinylogation reagent, the 2-lithio-1-trimethylsiloxyethylene, and to introduce the thymine moiety and to build the furanose ring in the same and last step.

Related Articles:

Solid??Phase Synthesis of Dipeptide??Conjugated Nucleosides and Their Interaction with RNA

[Dong, Guimin; Zhang, Liangren; Zhang, Lihe Helvetica Chimica Acta, 2003 , vol. 86, # 10 p. 3516 - 3524]

Solid??Phase Synthesis of Dipeptide??Conjugated Nucleosides and Their Interaction with RNA

[Dong, Guimin; Zhang, Liangren; Zhang, Lihe Helvetica Chimica Acta, 2003 , vol. 86, # 10 p. 3516 - 3524]

Synthesis and Anti??HIV Activity of Triazolo??Fused 3′, 5′??Cyclic Nucleoside Analogues Derived from an Intramolecular Huisgen 1, 3??Dipolar Cycloaddition

[Sun, Jingbo; Liu, Xinyu; Li, Hongming; Duan, Ronghui; Wu, Jinchang Helvetica Chimica Acta, 2012 , vol. 95, # 5 p. 772 - 779]

More Articles...