A convergent stereocontrolled synthesis of [3??14C] solanesol
…, MF Oldfield, N Geach, A Baxter
Index: Roe, Stephen J.; Oldfield, Mark F.; Geach, Neil; Baxter, Andrew Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 9-10 p. 485 - 491
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Citation Number: 6
Abstract
In this communication, we report the synthesis of~ 5 mCi of [3-14C] solanesol (1) prepared from ethyl [3-14C] acetoacetate and (all-E)-octaprenyl bromide (2) in four steps, with a specific radioactivity of 19.83 mCi/mmol and with a chemical/stereochemical and radiochemical purity of≥ 95%.(Figure 1). Position 3 of the chain was selected for 14C labelling because of the metabolic stability of this position. Unlabelled (all-E)-octaprenyl ( ...
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