Total synthesis of orellanine: The lethal toxin of Cortinarius Orellanus fries mushroom
M Tiecco, M Tingoli, L Testaferri, D Chianelli…
Index: Tiecco; Tingoli; Testaferri; et al. Tetrahedron, 1986 , vol. 42, # 5 p. 1475 - 1485
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Citation Number: 52
Abstract
The syntheses of the main toxin of Cortinarius Orellanus Fries, orellanine, and of its decomposition product, orelline, are reported. The structures of 3, 3', 4, 4'-tetrahydroxy-2, 2'- bipyridyl-N, N'-dioxide for orellanine and of 3, 3', 4, 4'-tetrahydroxy-2, 2'-bipyridyl for orelline have been proposed by WZ Antkowiak and WP Gessner. These two conpounds have now been synthesized starting from the 3, 3', 4, 4'-tetramethoxy-2, 2'-bipyridyl which could be ...
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