Chemical Communications

A one-step synthesis of fused pentathiepins

LS Konstantinova, OA Rakitin, CW Rees

Index: Konstantinova, Lidia S.; Rakitin, Oleg A.; Rees, Charles W. Chemical Communications, 2002 , # 11 p. 1204 - 1205

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Citation Number: 20

Abstract

Fused pentathiepins have attracted attention recently because of their stability, biological activity and high energy barrier for inversion of the chair-like pentathiepin ring. 1 The first naturally occurring examples varacin, 2 lissoclinotoxin A, 3,4 and N,N-dimethyl-7-(methylthio)varacin 5 have strong antimicrobial and antifungal activity, selectively inhibit protein kinase C, 5 and varacin is highly toxic towards human colon cancer HCT116. 2 The polysulfur ring of these ...

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