Quinoline-4-acetamides as sPLA 2 inhibitors

Y Liu, Y Feng, R Wang, Y Gao, L Lai

Index: Liu, Ying; Feng, Yabing; Wang, Renxiao; Gao, Ying; Lai, Luhua Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 13 p. 1639 - 1641

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Citation Number: 7

Abstract

Quinoline-4-acetamides were designed as potential phospholipase A2 inhibitors by structural based method and synthesized. The chemical structures of the obtained compounds were confirmed by elemental analyses, 1H NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certain inhibition to sPLA2.