Organic letters

A practical in situ generation of the Schwartz reagent. Reduction of tertiary amides to aldehydes and hydrozirconation

Y Zhao, V Snieckus

Index: Leighty, Matthew W.; Spletstoser, Jared T.; Georg, Gunda I. Organic Syntheses, 2012 , vol. 88, p. 427 - 437

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Citation Number: 35

Abstract

... a Yields are of isolated products. In summary, stimulated by the Georg report,(3a) we have discovered and developed an advantageous in situ protocol (Cp 2 ZrCl 2 /LiAlH(OBu-t) 3 for the ... The 4 compds. were characterized by ir spectra and by quant. hydrolysis with 50% aq. ...