Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A 2 and hyaluronidase enzymes

…, SK Murari, BS Vishwanth, S Shashikanth

Index: Khanum, Shaukath Ara; Murari, Satish Kumar; Vishwanth, Bannikuppe Sannanaik; Shashikanth, Sheena Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 18 p. 4100 - 4104

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Citation Number: 23

Abstract

Benzoylation of (hydroxy phenyl) phenyl methanone 2a–g to benzoyl phenyl benzoates 4a– g, a benzophenone analogue, was achieved in good yield. All the newly synthesized compounds were evaluated for their phospholipase A2 [EC 3.1. 1.4] and hyaluronidase [EC 3.2. 1.35] enzyme inhibitory activity in snake venom as source and their structure–activity relationship with respect to different groups is reported for the first time. The in vitro PLA2 ...