Condensed Heterotricycles. Synthesis and Reactions of b??Fused 1 (2H)??Isoquinolinones with unusual enaminic properties

…, SJ Shenoy, H Fritz, WJ Richter, D Muller

Index: Nagarajan; Rao; Shah; Shenoy; Fritz; Richter; Muller Helvetica Chimica Acta, 1988 , vol. 71, # 1 p. 77 - 92

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Citation Number: 21

Abstract

Abstract Homophthalic acid (1) undergoes reaction with 1, 2-, 1, 3-, and 1, 4-diamines to give condensed 1 (2H)-isoquinolinones like 2, 4, 13, and 25, which exhibit marked enamine character. These are attacked by electrophiles at the N or C terminus. Some notable reactions of imidazoisoquinolone 2 are those with maleic and acrylic acids to form the tetracycles 48 and 51, respectively. With propiolic acid, 5 underwent an interesting ...