Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice

…, S Sharma, LP Gupta, P Ahmad, SP Srivastava…

Index: Kumar, Atul; Sharma, Siddharth; Gupta, Lalit Prakash; Ahmad, Pervez; Srivastava, Swayam Prakash; Rahuja, Neha; Tamrakar; Srivastava, Arvind K. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2172 - 2179

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Citation Number: 3

Abstract

A series of propiophenone derivatives (6–23) have been synthesized and evaluated for their in vivo antihyperglycemic activities in sucrose loaded model (SLM), sucrose challenged streptozotocin (STZ-S) induced diabetic rat model and C57BL/KsJ db/db diabetic mice model. Compound 15 and 16 were emerged as potent antihyperglycemics and lipid lowering agents. These compounds (15, 16) further validate the potency by reducing body ...