Tetrahedron letters

Cobalt (II) catalyzed tosylation of alcohols with p-toluenesulfonic acid

S Velusamy, JSK Kumar, T Punniyamurthy

Index: Velusamy, Subbarayan; Kumar, J. S. Kiran; Punniyamurthy Tetrahedron Letters, 2004 , vol. 45, # 1 p. 203 - 205

Full Text: HTML

Citation Number: 20

Abstract

Cobalt (II) chloride hexahydrate (CoCl2· 6H2O) has been found to catalyze the tosylation of both aliphatic and aromatic alcohols with p-toluenesulfonic acid (p-TsOH) in high yields in 1, 2-dichloroethane under reflux (ca. 80° C). In the case of aliphatic alcohols, secondary alcohols undergo tosylation chemoselectively in the presence of primary hydroxy groups.