Evaluation of Novel 7-(hetero) aryl-substituted Pyrazolo [1, 5-a] pyrimidines as Phosphodiesterase-4 Inhibitors

…, R Gupta, K Venkata Laxmi Parsa…

Index: Kodimuthali Arumugam; Gupta, Rajesh; Parsa, Kishore Venkata Laxmi; Prasunamba, Padala Lakshmi; Pal, Manojit Letters in Drug Design and Discovery, 2010 , vol. 7, # 6 p. 402 - 408

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Citation Number: 12

Abstract

A novel series of 7-(hetero) aryl substituted-pyrazolopyrimidines, prepared via an AlCl3 induced CC bond forming reaction of 7-chloro-5-phenyl-pyrazolo [1, 5-a] pyrimidine with arenes and heteroarenes have been investigated as PDE4 inhibitors. Among all the compounds tested the 7-indolyl substituted pyrazolopyrimidine showed good inhibition of PDE 4 in vitro.