Synthesis of novel 2-alkyl triazole-3-alkyl substituted quinoline derivatives and their cytotoxic activity

…, B Veeraswamy, GS Kumar, PS Rao, R Pamanji…

Index: Sambasiva Rao; Kurumurthy; Veeraswamy; Santhosh Kumar; Shanthan Rao; Pamanji; Venkateswara Rao; Narsaiah Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1225 - 1227

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Citation Number: 16

Abstract

The propargyl alcohol on reaction with alkylazides under Sharpless conditions through click chemistry concept gave exclusively 1, 4-disubstituted triazoles 2. The compounds 2 were oxidized to aldehydes 3 followed by reaction with aniline resulted Schiff's bases 4. The compounds 4 was further reacted with various aldehydes having α-hydrogen using molecular iodine as a catalyst and obtained 2-alkyl triazole-3-alkyl substituted quinoline ...