Reactions of 3, 5-di-tert-butyl-4-hydroxybenzyl acetate with weakly basic nucleophiles

…, GN Nugumanova, NA Mukmeneva

Index: Bukharov; Nugumanova; Mukmeneva Russian Journal of General Chemistry, 2003 , vol. 73, # 3 p. 408 - 412

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Abstract

Abstract-The acid dissociation of 3,5-di-tert-butyl-4-hydroxybenzyl acetate in the presence of bases or in dimethylformamide favors reaction of this compound with weakly basic nucleophilies. ... 3,5-Di-tert-butyl-4-hydroxybenzyl acetate (I) is a highly active reagent which allows synthesis in mild conditions and in high yields of compounds compris- ing sterically congested phenol fragments [1]. Earlier we found that acetate I readily reacts with primary and ...