Diastereoisomers of 2-benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol: Potential anti-inflammatory agents

…, M Jordan, T McCabe, E Passante, NH Frankish

Index: Sheridan, Helen; Walsh, John J.; Cogan, Carina; Jordan, Michael; McCabe, Tom; Passante, Egle; Frankish, Neil H. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 20 p. 5927 - 5930

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Citation Number: 17

Abstract

The synthesis and biological activity of the novel diastereoisomers of 2-benzyl-2, 3-dihydro- 2-(1H-inden-2-yl)-1H-inden-1-ol is reported. The 2, 2-coupled indane dimers were synthesised by coupling of the silyl enol ether of 1-indanone with the dimethyl ketal of 2- indanone. The coupled product was directly alkylated to give the racemic ketone which was reduced to the diastereoisomeric alcohols. The alcohols were separated and their relative ...