Synthesis and structure–activity relationship of nuciferine derivatives as potential acetylcholinesterase inhibitors

…, Z Song, W Xue, J Sheng, Z Shu, Y Shi, J Liang…

Index: Yang, Zhongduo; Song, Zhuwen; Xue, Weiwei; Sheng, Jie; Shu, Zongmei; Shi, Yin; Liang, Jibei; Yao, Xiaojun Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 3178 - 3186

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Citation Number: 8

Abstract

Abstract Acetylcholinesterase inhibitors (AChEIs) are currently the best available pharmacotherapy for Alzheimer patients, but because of bioavailability issues, there is still great interest in discovering better AChEIs. The aporphine alkaloid is an important class of natural products, which shows diverse biological activity, such as acetylcholinesterase inhibitory activity. To find new lead AChEIs compounds, eight aporphine alkaloids were ...