Leukotrienes and other products of the 5-lipoxygenase pathway: biochemistry and relation to pathobiology in human diseases

RA Lewis, KF Austen…

Index: Smet, Mario; Dehaen, Wim Molecules, 2000 , vol. 5, # 3 p. 620 - 628

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Citation Number: 1232

Abstract

... The molecular activation of the 5-lipoxygenase pathway begins with cell stimulation, when the enzyme ... cis-8,10-trans-eicosatetraenoic acid (20-CHO LTB 4 ), a biologically inactive molecule. ... to degrade them is also enhanced, further limiting the local effects of these molecules. ...