Tetrahedron letters

Novel erythromycin A derivatives: synthesis of 11, 12-benzoxazine ketolides

B Zhu, A Maden, MJ Macielag

Index: Zhu, Bin; Maden, Amy; Macielag, Mark J. Tetrahedron Letters, 2005 , vol. 46, # 11 p. 1783 - 1785

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Citation Number: 5

Abstract

A novel series of 11, 12-benzoxazine ketolide derivatives of erythromycin A has been synthesized. The C11, C12-benzoxazine structure was constructed stereoselectively through an intramolecular Michael addition of a C12-O-(2-aminophenyl) group to the enone