Synthesis and antiviral evaluation of novel open-chain analogues of neplanocin A

JH Hong, SY Kim, CH Oh, KH Yoo…

Index: Hong, Joon; Kim, So-Young; Oh, Chang-Hyun; Yoo, Kyung; Cho, Jung-Hyuck Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 3 p. 341 - 350

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Citation Number: 4

Abstract

Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with purine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds Ia–II were evaluated for their antiviral activity against various viruses such as HIV, HSV-1, HSV-2, and ECMV.