Tetrahedron

Facile synthesis of dihaloheterocycles via electrophilic iodocyclization

F Yang, T Jin, M Bao, Y Yamamoto

Index: Yang, Fan; Jin, Tienan; Bao, Ming; Yamamoto, Yoshinori Tetrahedron, 2011 , vol. 67, # 52 p. 10147 - 10155

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Citation Number: 27

Abstract

An efficient and facile electrophilic iodocyclization for the synthesis of various O-, N-, and S- containing dihaloheterocycles has been developed. A wide range of the substituted propargyl alcohols having–OH,–NTs, and–SAc functional groups reacted with molecular iodine or bromoiodine at ambient temperature to produce the corresponding dihalogenated O-, N-, and S-containing five-and six-membered heterocycles in good to high yields; ...