Tetrahedron letters

Total synthesis of haliclamine A, a macrocyclic marine alkaloid related to the key biogenetic intermediate of manzamines

Y Morimoto, C Yokoe

Index: Morimoto, Yoshiki; Yokoe, Chiho Tetrahedron Letters, 1997 , vol. 38, # 52 p. 8981 - 8984

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Citation Number: 31

Abstract

The first total synthesis of haliclamine A (1), a macrocyclic marine alkaloid closely related to the key bisdihydropyridine intermediate 3 of the biogenetically unique manzamine family, has been efficiently achieved via stepwise inter-and intramolecular N-alkylations of 3- alkylpyridine derivatives 26 and 28.