Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus
GD Diana, D Cutcliffe, RC Oglesby…
Index: Diana, Guy D.; Cutcliffe, David; Oglesby, Richard C.; Otto, Michael J.; Mallamo, John P.; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 450 - 455
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Citation Number: 54
Abstract
A number of 2, 6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes. A QSAR study revealed that the mean MIC (m) against five rhinovirus serotypes correlated well with log P. The 2, 6-dichloro analogue, 15, was highly effective in vitro against rhinoviruses with an MI& of 0.3 pM, as well as against several enteroviruses, and was also effective in ...
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