A model for compounds active against human rhinovirus-14 based on X-ray crystallography data

GD Diana, AM Treasurywala, TR Bailey…

Index: Diana; Treasurywala; Bailey; Oglesby; Pevear; Dutko Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1306 - 1311

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Citation Number: 29

Abstract

Recent X-ray crystallographic studies performed on compounds in this series having five- and seven-carbon chains connecting both ends of the molecules have shown that the compounds bind in the pocket in one of two orientations." Compounds with a seven-carbon chain and a substituent on the oxazoline ring are bound in one orientation, while those with a five-carbon chain, regardless of the substitution pattern, are bound in the opposite ...