Tetrahedron

Chiral carbamates through an enzymatic alkoxycarbonylation reaction.

M Pozo, V Gotor

Index: Pozo, Marcos; Gotor, Vicente Tetrahedron, 1993 , vol. 49, # 20 p. 4321 - 4326

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Citation Number: 56

Abstract

Carbamate derivatives am products of considerable interest in some areas of Medicinal Chemistry.1 An alkaloid, physostigmine, which has a carbamate moiety in its structure, is currently undergoing clinical trials for the treatment of Alzheimer's DiseaseJThe preparation of carbamate analogues of physostigmine has recently been reported3 and one of these compounds has been found to be a potent cholinesterease inhibitor. Some carbamates have been exploited in ...