5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl) benzyl]-5-(5-methylpyridin-2-ylmethoxy)- …

…, A Santini, J Darlington, P Prodanovich…

Index: Stock, Nicholas S.; Bain, Gretchen; Zunic, Jasmine; Li, Yiwei; Ziff, Jeannie; Roppe, Jeffrey; Santini, Angelina; Darlington, Janice; Prodanovich, Pat; King, Christopher D.; Baccei, Christopher; Lee, Catherine; Rong, Haojing; Chapman, Charles; Broadhead, Alex; Lorrain, Dan; Correa, Lucia; Hutchinson, John H.; Evans, Jilly F.; Prasit, Peppi Journal of Medicinal Chemistry, 2011 , vol. 54, # 23 p. 8013 - 8029

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Citation Number: 25

Abstract

The potent 5-lipoxygenase-activating protein (FLAP) inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6- ethoxypyridin-3-yl) benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1 H-indol-2-yl]-2, 2- dimethylpropionic acid 11cc is described (AM803, now GSK2190915). Building upon AM103 (1)(Hutchinson et al. J. Med Chem. 2009, 52, 5803–5815; Stock et al. Bioorg. Med. Chem. Lett. 2010, 20, 213–217; Stock et al. Bioorg. Med. Chem. Lett. 2010, 20, 4598– ...