Synthesis of [2H4] oxymetazoline and [14C] oxymetazoline

…, S Borges, S Ren, P McNamara

Index: Brugger, Michelle L.; Borges, Scott; Ren, Sumei; McNamara, Paul Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 14 p. 793 - 795

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Abstract

Abstract An efficient synthesis of [2 H 4] and [14 C] oxymetazoline has been developed. Both compounds follow the same synthetic route with the introduction of the label occurring at different synthetic steps. The synthesis of [2 H 4] oxymetazoline from [2 H 4] ethylene diamine was achieved in one step with a 40% yield. The synthesis of [14 C] oxymetazoline from potassium [14 C] cyanide was achieved in two steps with an overall radiochemical ...