A modular and organocatalytic approach to γ-butyrolactone autoregulators from Streptomycetes

…, H Jiang, JB Nielsen, F Pasi, KA Jørgensen

Index: Elsner, Petteri; Jiang, Hao; Nielsen, Johanne B.; Pasi, Filippo; Jorgensen, Karl Anker Chemical Communications, 2008 , # 44 p. 5827 - 5829

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Citation Number: 10

Abstract

A general synthesis of optically active γ-butyrolactone autoregulators is developed by a two- step sequence to assemble 2, 3-trans-disubstituted butyrolactones in high yields and enantioselectivities; the scope of this reaction was elaborated by setting up a library of alkyl- substituted butyrolactones and the synthesis of the autoregulators IM-2 and VB-D.