Addition of organolithium reagents to α-(trifluoromethyl) styrene: concise synthesis of functionalised gem-difluoroalkenes

JP Bégué, D Bonnet-Delpon, MH Rock

Index: Begue, Jean-Pierre; Bonnet-Delpon, Daniele; Rock, Michael H. Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 12 p. 1409 - 1413

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Abstract

The treatment of α-(trifluoromethyl) styrene with organolithium reagents results in the selective formation of gem-difluoroalkenes in good-to-excellent yields. This reaction has been applied to the synthesis of 3-gem-difluoro-2-phenylallylic amines and other functionalised gem-difluoroalkenes.