Tetrahedron

Direct arylation of azine N-oxides with aryl triflates

DJ Schipper, M El-Salfiti, CJ Whipp, K Fagnou

Index: Schipper, Derek J.; El-Salfiti, Mohamed; Whipp, Christopher J.; Fagnou, Keith Tetrahedron, 2009 , vol. 65, # 26 p. 4977 - 4983

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Citation Number: 70

Abstract

Palladium catalyzed direct arylation of azine N-oxides using aryl triflates to afford the corresponding 2-aryl azine N-oxides is described. The reaction is carried out with a range of both N-oxides and aryl triflates. The arylation can be carried out in sequence to yield differentially diarylated products. The regioselectivity and scope of 3-substituted azine N- oxides are investigated. The method is applied to the synthesis of a compound that ...