N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated γ-secretase

…, K Baumann, R Schubenel, C Haass, H Steiner…

Index: Narlawar, Rajeshwar; Perez Revuelta, Blanca I.; Baumann, Karlheinz; Schubenel, Robert; Haass, Christian; Steiner, Harald; Schmidt, Boris Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 176 - 182

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Citation Number: 32

Abstract

N-Sulfonylated and N-alkylated carbazolyloxyacetic acids were investigated for the inhibition and modulation of the Alzheimer's disease associated γ-secretase. The introduction of a lipophilic substituent, which may vary from arylsulfone to alkyl, turned 2- carbazolyloxyacetic acids into potent γ-secretase modulators. This resulted in the selective reduction of Aβ42 and an increase of the less aggregatory Aβ38 fragment by several ...